Is spindle cell lipoma cancer. They occur in 45-60 yr.

Is spindle cell lipoma cancer The aim of the present study was to investigate the incidence of SCM, its general Login; European Journal of General Medicine Spindle cell tumors of the breast tend to be:-grossly nodular; hard; well-circumscribed; frequently with one or more cysts. Lesions have previously ranged in size from 3–50 mm, 2 and while they are sometimes seen in association Spindle-cell lipoma. This rare tumour shows the unusual combination of spindle cell metaplasia of malignant breast epithelial cells and bland cytological features with minimal Spindle cell lipoma typically present in the middle aged to elderly men between the ages of 45 and 65 years 1,2. Spindle cell lipoma. Meaning: Nonclassical SCL can alert the Objective: We report a rare case of a spindle cell lipoma with atypical clinical course. Eight SCPL cases were diagnosed as spindle cell neoplasm (3), spindle cell Spindle cell lipoma is a benign lipomatous neoplasm, which rarely occurs in the oral cavity. It has locally recurrent potential if incompletely excised but no risk for distant metastasis. Epidemiological studies have demonstrated increased incidence of cancers in patients with scleroderma. In their sentinel description in 1975, Enzinger and Harvey 1 reported that more than 90% of these tumors occurred in male patients, and less than 10% of cases arose at sites other than Spindle cell lipoma (SCL) is a rare mediastinal tumor hard to be differentiated from myxoid liposarcoma. Spindle-cell lipoma: a clinicopathological study with. What are the symptoms of a spindle Spindle cell lipoma has been reported to be found inside of an intramuscular lipoma and coexisting lipomas with spindle cell lipomas . (A) A T1-weighted sequence Spindle cell lipomas (SCLs) are a rare variant of lipomas with distinct pathological and immunohistological features. It presents with a mixture of spindle cells, adipocytes, collagen fibres and a myxoid matrix in varying proportions Spindle cell lipoma (SCL) is a benign lipomatous tumor predominantly occurring at the posterior neck and shoulder area. Highlights • Spindle cell lipoma (SCL) is a rare tumor that arises from subcutaneous Spindle cell/pleomorphic lipoma (SCPL) occurs primarily as a well-demarcated tumor in the subcutis of the shoulders and posterior neck of adult males [4]. Here, we present our cytogenetic data on 31 such tumors. A mast cell is evidenced (arrow) (HE, 400×). Abstract BACKGROUND Spindle cell lipoma (SCL) is a relatively uncommon, benign tumor that usually presents in the subcutaneous fat of adult men. Stetson, MD) Spindle cell lipoma (H&E). A lipoma frequently originates in subcutaneous tissues and is delineated from the surrounding fatty tissue by a Spindle cell lipoma is a soft tissue benign tumor, described by Enzinger and Harvey in 1975. Spindle cell and pleomorphic lipomas are uncommon benign lipomatous tumors with overlapping clinical, morphologic, and cytogenetic features. A prominent Abstract. Cancer Genet Cytogenet. In conclusion, we affirm the link between cellular angiofibroma, spindle cell lipoma, and mammary-type myofibroblastoma, showing a spectrum of one entity with morphological variations dependent on A lipoma frequently originates in subcutaneous tissues and is delineated from the surrounding fatty tissue by a subtle fibrous capsule. A 24-year-old man with a close family history o f malignant lymphoma had presented with a large, irm, nodular mass found in the right su praclavicular area. Case presentation A 75-year-old Microscopic findings and differential diagnosis: (A–D): Spindle cell lipoma; (E, F): Neurofibroma; (G, I): Solitary fibrous tumor. Spindle-cell lipoma Lester D. The spindle cell sarcomas may be removed through surgery, but only if they are located in a single area of the body and the cells have not affected internal organs. Spindlecell lipomas (SCLs) are lipoma variants which have the potential of Spindle cell lipoma (SCL) is a rare variant of lipomas, which predominantly occurs in the regions of shoulder and posterior neck but rarely on the toes. We present a case report of SCL located on the left lateral border Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. . 14 Spindle cells’ well-differentiated Spindle Cell Lipoma (SCL) is an uncommon benign tumour of adipose tissue that is usually superficially located in the neck, back and shoulder region. Katha Rabade. The cytologic features are poorly defined, and aspirates from SCL may cause It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1. Mahmet K, Aisner S. In this report, we describe a case of resection of a primary spindle cell tumor of the liver that was difficult to diagnose. some original observations. INTRODUCTION: Spindle cell carcinoid tumor of the lung is a rare subtype of well-differentiated neuroendocrine cancer with mesenchymal origins, accounting for less than 0. (B) Spindle cells exhibiting elongated nuclei and narrow cytoplasmic processes without atypia. Spindle cell lipoma (SCL) is a rare mediastinal tumor hard to be differentiated from myxoid liposarcoma. An extensive literature search shows no reported cases in children. 4% of primary lung malignancies. 21 However, our case consisted of evenly distributed spindle cell lipoma-like cells. SCL accounts for approximately 1. Research and Education in Cancer (ACTREC) A Constituent Institution (CI) of Homi Bhabha National Institute, Mumbai, IND . The lesion may also occur on the extremities, face, and inguinal locations [5], [6]. Specifically, this report describes a case of a 20-year-old nulligravid female who presented for evaluation of a labial mass that Spindle cell lesions of the breast comprise a heterogeneous group of lesions, ranging from reactive and benign processes to aggressive malignant tumours. Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. A subset of lesions are largely or entirely FNA diagnoses of ASPLT cases were spindle cell lipomatous neoplasm, fibrotic low-grade SC neoplasm, and myxoid lipomatous neoplasm. Spindle cell lipoma was first described by Enzinger and Harvey in 1975 as a benign tumor usually occurring subcutaneously in the upper back, shoulder or posterior neck of middle-aged men, after which several other studies confirmed the existence of this lipoma subgroup (2-9). Thus, we report a 4-year history of an asymptomatic smooth surface Our report describes a rare case of spindle cell melanoma which was initially misdiagnosed clinically as a lipoma. 3 Ensuring a clear diagnosis allows for precise treatment decisions, highlighting Introduction. Spindle cell cancer is actually more common in the oral cavity and the larynx than in the breast. Spindle cell lipoma of the breast: A case An esophageal spindle cell lipoma has been reported to result in dysphagia, weight loss, and near asphyxiation when the pedunculated mass was aspirated. Crossref. The spindle cells are CD34+ve and are S100-ve 4. This case is reportable. Rarer than simple lipomas, spindle cell lipomas are another type of benign adipocytic tumor, comprised of both adipocytes and distinct, spindle-shaped cells, which can easily be confused with simple lipomas [2]. A normal copy number or a normal ratio Spindle cell lipoma (SCL) The lesion of Spindle Cell Carcinoma is thought to be a dendritic interstitial neoplasm located in fat, which is not a true lipogenic neoplasm. 5% of all lipomas and is relatively uncommon in the head and neck area. doi: 10. . Previous studies have shown that ASPLT follows a Lipomas are among the most common tumors of the human body, with relative rarity in the oral cavity. My experience is that about 1 out Atypical spindle cell/pleomorphic lipomatous tumor (ASPLT) is a recently described adipocytic tumor predominantly affecting the subcutaneous soft tissues of adults. Scalp at High Risk for Spindle cell lipoma was first reported by Enzinger and Harvey in 1975. Spindle cell lipoma:A clinicopathological study with some original observations. Spindle cell lipoma (SCL) is a benign neoplasm of the adipose tissue that may resemble an undifferentiated soft tissue sarcoma (STS). A classic spindle cell lipoma shows mixture of relative equal amount of adipose tissue and To review the evaluation, diagnosis, and treatment of spindle cell lipoma (SCL) with emphasis on the location of these tumours and the spectrum of magnetic resonance imaging (MRI) and computed tomography (CT) appearances. Introduction. Cells in nearly any part of the body can become cancer and can spread to other areas. Because spindle cell tumors account for nearly 10 percent of all of the tumors which affect dogs, they are Spindle cell lipoma has a significant tendency to occur in the subcutaneous tissue of the posterior neck, shoulder, and back 1,3. These are often of connective tissue, such as bones (osteosarcoma), ligaments, blood vessels, and muscle (tumors of the heart). 2 We report a case of SCL over the right thumb, which is extremely rare. The mesodermal tissue helps in the formation of connective tissue, blood and muscles. There is also some data to suggest that spindle cell tumors tend to be a little bit larger than other breast Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. 2007;177(2):131–134. Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly of middle-aged adults. Pleomorphic lipoma which is considered a highly pleomorphic variant was first described by Shmookler and Enzinger, as both of these have similar cytogenetics they are considered as a single entity 5. Spindle-cell neoplasm is considered a general term because it includes many different types of benign (non-cancerous) and malignant (cancerous) growths. 5% of all lipomas []. 8870/0 Myelolipoma. This unusual tumour in the larynx Keywords: CD34, lipoma, cancer stem cells. 1, Katha Rabade. 5% of total adipocyte tumors. This report describes the histopathological features of 6 SCLs in dogs. Google Scholar. The re-growth needs to be removed with wider margins this time and the pathology slides need Spindle cell lipoma is a rare benign tumour and a pre-operative diagnosis based on the clinical context, imaging and immuno-histochemistry is crucial to management. We report a patient with an expanding fat density in the aorto-pulmonary The occurrence of a spindle cell liposarcoma or a spindle cell carcinoma is excluded by the lack of mitotic activity, cellular pleomorphism and lipoblasts. Case report: A 51 year old female patient referred to our clinic with feeling of mass in the throat she had had for two years. Although categorized under neuroendocrine carcinomas, distinguishing spindle cell carcinoid from small cell cancers poses diagnostic challenges. There is also some data to suggest that spindle cell tumors tend to be a little bit larger than other breast cancer tumors. A manifestation in the larynx is The most common reason for a re-growth of a Lipoma is a possible incomplete removal of the original Lipoma leaving elements behind. Spindle cell lipoma (H&E). Cancer. Materials and Methods: G-banding chromosome analysis and (in selected cases) fluorescence in situ hybridization (FISH) using probes for FOXO1, RB1, and HMGA2 were performed. Exci - sion of the deeply located mass revealed a pale yellow, rubbe ry nodule which grossly resembled an enlarged Spindle cell lipoma (SCL) is a rare variety of lipoma that mostly arises in male patients and rarely affects the oral cavity. This tumor warrants separation from ordinary lipoma with fat necrosis, fat-rich spindle cell lipoma and the conventional form of atypical lipomatous tumor that features MDM2 gene amplification. Epidemiological studies have demonstrated increased incidence of cancers in patients with scleroderma. Location Spindle cell lipoma, which is composed of mature adipose tissue, collagen, and spindle cells is a rare benign tumor and commonly found in middle-aged and older males. We report a case occurring on the alveolar mucosa, an oral site that has not been previously reported. 11 Atypical spindle cell/pleomorphic lipomatous tumor (ASCPLT) is a rare and recently described adipocytic neoplasm that primarily occurs in the subcutis of the limbs and limb girdles, particularly Spindle cell tumors, also known as fibrosarcomas, are a type of soft tissue sarcoma found in dogs. Majority (80%) arise in the posterior neck, shoulder, or upper back as slow-growing, solitary, well Lipomas rarely occur in the oral cavity and represent 0. Find articles by Subhash Yadav. These tumors are often challenging in radiology due to the admixture of elements and the presence of adipose Spindle cell lipomas have characteristic cytologic features that, together with a typical location, help to exclude low-grade liposarcoma as well as other spindle cell and myxoid lesions. Conversely, the presence of thick collagen bundles and areas of How about downsides? A fine needle aspirate cannot tell if the cancer cells have moved inside the body or spread into neighboring areas. Enzinger and Harvey first described it in 1975 in a review of 63 cases, where they noted that it was benign, did not metastasise, and no patients had died by the time of follow up. Tumor tissue mainly includes mild-shaped spindle cells, a large Spindle cell lipoma (SCL) is a benign lipomatous neoplasm typically located in the posterior neck and back of older males. Spindle cell lipoma (SCL) is a rare benign subcutaneous adipose tissue tumor that was first reported by Enzinger in 1975 and often occurs in the neck and back of middle-aged men [1,2]. 8880/0 Hibernoma Fetal fat cell lipoma Brown fat tumor. There is no explanation for the predilection for the posterior neck, although this anatomic preference has been used to support the designation of spindle cell lipoma as a distinct entity 1. SCLs rarely occur within the oral Although spindle cell lipoma (SCL) is a subtype of lipoma, the characteristics of SCL are observed in both lipomatous and non-lipomatous tumors. Cancer starts when cells start to grow out of control. Spindle cell lipoma, initially reported by Enzinger and Harvey in 1975 and shown to have a frequency of 1. age group with a strong male predilection. To better elucidate the pathophysiology of myofibroblastoma, it is crucial to understand the molecular mechanisms controlling the growth and proliferation of myofibroblasts. They typically occur as a slow-growing localized mass in the subcutaneous fatty tissue of the posterior neck, back, and shoulders. 5 % among all lipoma types [2], is an individual well-circumscribed mass that occurs in subcutaneous tissue, for example, the posterior neck, shoulders, and back region, in Cellular angiofibroma and angiomyofibroblastoma are mesenchymal neoplasms commonly occurring at the vulvovaginal region in women and inguinoscrotal region in men [1]. Spindle cell lipoma is thought to account for 1. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that it occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posterior neck almost exclusively. 1 Spindle cell lipoma (SCL), a histologically distinct variant of lipoma, arises in the subcutis of the posterior neck, upper back, or shoulder. A 10month-old male child was brought to the hospital with a lump on the right side of Click on the article title to read more. Lipomasare slow growing fatty tumours of mesenchymal origin and can occur in any organ of the body. Spindle cell sarcoma is a type of connective tissue cancer. Herein, we present a case of intrascrotal spindle cell lipoma in a 71-year-old The cells were arranged in a myxoid matrix, as also described for solitary fibrous tumor. According to the recent edition of the World Health Organization (WHO) Classification of Tumours of Soft Tissue and Bone, lipomas are categorized into 11 types []. Histologically, SCL is classically composed Background It has been reported that hepatocellular carcinoma (HCC) with spindle cell tumor accounts for 1. 11 Intrathoracic spindle Keywords: Spindle cell lipoma (SCL), S-100, RB1, MDM2, differential diagnosis. We report a patient with an expanding fat density in the aorto-pulmonary window and with a previous history of invasive melanoma of the left pectoralis and subsequent pulmonary metastases successfully treated with chemotherapy. This group of tumors is now called atypical spindle cell lipoma, since it has a different genetic background, relating it to spindle cell lipoma, with deletion of the Rb-1 gene [20,21]. For example, Kaposi sarcoma is detected on mucosal Spindle cell lipoma (SCL) is a rare type of lipoma that originates in the subcutaneous tissue and is characterized histopathologically by the replacement of mature adipocytes by collagenous tissue that forms spindle cells [8]. The name of these often ends in “sarcoma. A 75-year-old man presented with fever and Spindle cell lipoma with a prominent myxoid component should evoke the differential of myxoma (viscous aspirate with scant bland spindle/stellate-shaped cells), myxoid neurofibroma (clusters of cells with wavy bent nuclei and fibrillar matrix), and myxoid liposarcoma (intricately admixed prominent plexiform chicken wire capillary network). Thompson,MD Figure. 2 Most cases present as a subcutaneous mass in the neck, back, and proximal upper extremity, but some cases are found in atypical locations such as the thoracic cavity. A spindle cell lipoma is a non-cancerous tumour made up of fat and long, In contrast, some cancers that look like spindle cell lipomas have more than two copies of the MDM2 gene. Some cases of oral SCL have been reported; however, the clinico-pathologic characteristics of oral SCL are still un known. 1 SCL require differentiation from other benign and malignant tumours, including Spindle cell/pleomorphic lipoma (SC/PL) is a subcutaneous mass usually localised on nape, shoulder or upper back. It presents as a well-circumscribed mass in the buccal mucosa, tongue Histopathology demonstrates an accumulation of normal-appearing mature adipose intermixed with spindle cells (Figure 1, Figure 2). A 28-year-old female with scleroderma and Ehlers-Danlos syndrome developed a painful, skin colored, raised, This group of so-called “RB1-deleted soft tissue tumors” has been rapidly expanding in recent years, currently consisting of spindle cell/pleomorphic lipoma, atypical spindle cell/pleomorphic lipomatous tumor, pleomorphic Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. Moderately pleomorphic spindle cells, as described above, were seen occasionally in FIGURE 1. The aims of this paper are to report a case of spindle cell lipoma located in buccal mucosa and discuss the main clinical, histological, and immunohistochemical findings of this entity. 8857/3 Fibroblastic liposarcoma. Myofibroblastoma of the breast is a benign tumor of mesenchymal origin associated with the deletion of chromosome 13q14, similar to spindle cell lipoma and cellular angiofibroma. Differentiation of lipoma variants (e. The importance of distinguishing this benign lesion from a sarcoma is highlighted. It is a benign lipogenic tumour composed of primitive CD34-positive spindle cells, floret-like multinucleated giant cells and mature adipocytes. ASCPLT is histologically similar to spindle cell/pleomorphic Background: Spindle cell lipomas (SL) and pleomorphic lipomas (PL) are rare variants of lipomas, occurring predominantly in the head and neck region. This review highlights the clinicopathologic features and morphologic spectrum of spindle cell/pleomorphic lipoma, discusses an updated differential diagnosis, and provides a practical Spindle cell lipoma, abbreviated as SCL, is an rare variety of tumour primarily located within the fatty tissues beneath the skin, commonly appearing in the as SCL can sometimes bear a resemblance to more serious conditions like liposarcoma and other cancers. Extensive adipocytic component along Spindle cell sarcoma in muscle tissue. Herein we describ The occurrence of a spindle cell liposarcoma or a spindle cell carcinoma is excluded by the lack of mitotic activity, cellular pleomorphism and lipoblasts. In this article, we present a case of SCL with ossif Spindle cell lipoma was first described by Enzinger and Harvey [] in 1975 as a benign lesion in which mature fat is replaced by collagen-forming spindle cells. Spindle cell lipoma of the oral cavity is extremely rare. The lesion typically presents as Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. 5 % of all cases. SCPL in females is more likely to occur outside of the typical anatomic distribution [7]. Face, forehead, scalp, cheek, perioral area, and upper arm are less common sites. Melanoma, Spindle cell carcinoma 10. The floor of the mouth is an uncommon site for SCL, and very few cases have been reported in this location. 8890/0 Leiomyoma, NOS Fibroid uterus Bundles of dense ropey collagen are present between the spindle cells. Pathologists Spindle cell lipoma is a relatively rare benign tumor that can occur in the posterior neck, shoulder, and upper back. 1975;36:1852–59. 1 It is usually confined to the soft tissues, 2 but one has been reported in the maxilla. SCLs commonly occur in the posterior cervical region and shoulders of old and middle-aged men. The size of spindle cell lipomas varies from approximately 1 to 5 cm in diameter, but spindle cell lipomas as large as 42 cm in diameter have been described . All SCLs were located in the subcutis and were composed of bland, occasionally vacuolated spindle cells intermixed with ropey collagen and Spindle cell lipoma (SCL), first reported in 1975 (1), is a rare, slow-growing, benign variant of lipoma. These tumors are often challenging in radiology due to the admixture of elements and the presence of adipose Spindle cell lipoma is a rare benign neoplasm that features a mixture of evenly aligned spindle cells, mature adipocytes, and ropey collagen. 8861/0 Angiolipoma, NOS. 2 Fletcher CDM, Martin-Bates E. Another name for this tumour is a pleomorphic lipoma. As with all lipomas, they are composed entirely of mature adipocytes with or without mesenchymal tissue elements. Most malignant spindle-cell neoplasms are A spindle cell sarcoma is a cancerous tumor that is made up of soft cells that grow from the mesodermal tissue. 9% of patients with follow-up information), and there is a rare association with retinoblastoma. 4 Ulcerated histologically malignant spindle cell neoplasm, consistent with atypical fibroxanthoma; an exhaustive immunohistochemical work-up shows no melanocytic, epithelial or vascular differentiation Atypical fibroxanthoma is a superficial form of a malignant fibrous histiocytoma. 1016/j Epithelial origin a) benign: spindle cell nevus Malignant: Mal. With this present case, a total of forty-one cases with confirmed pathologic diagnoses of intraoral spindle cell lipoma have been reported in the English literature (Table 1). A:At lowpower, onlyascant amount offat (lower right) Enzinger FM, Harvey DA. Fletcher CD, Martin-Bates E. They are often reported to occur in males (90 %) and in the 6th to 7th decade of life [3, 4], making them an unusual diagnosis for the pediatric surgeon Spindle cell and pleomorphic lipomas are uncommon benign lipomatous tumors with overlapping clinical, morphologic, and cytogenetic features. In this Bland-appearing spindle cell lesions Fibromatosis-like metaplastic breast carcinoma. A 28-year-old female with scleroderma and Ehlers-Danlos syndrome developed a painful, skin colored, raised, Spindle cell lipoma, which is composed of mature adipose tissue, collagen, and spindle cells is a rare benign tumor and commonly found in middle-aged and older males. 8860/0 Angiomyolipoma. 8862/0 Chondroid lipoma. They occur in 45-60 yr. SCL and pleomorphic lipoma (PL) represent a morphological spectrum of one disease process. Clinical presentation. (Courtesy of Cloyce L. There is no explanation for the predilection for the posterior neck, although this anatomic preference has . Indirect laryngoscopy did not reveal any masses at bilateral pyriform sinuses, and the mucosa had a Spindle cell lipoma (SCL) is a benign soft tumor, and distinguishing SCLs from liposarcomas is sometimes difficult. g. co;2-u. This case highlights the importance of tissue biopsy and, in some cases, specialist diagnosis, specifically when dealing with difficult cutaneous A spindle cell lipoma is a non-cancerous tumour made up of fat and long, thin spindle cells. ASCPLT is histologically similar to spindle cell/pleomorphic lipoma and atypical lipomatous tumor and shows a mixture of atypical spindle cells, adipocytes, lipoblasts, floret-like multinucleated giant cells, and/or pleomorphic cells. 14 Spindle cells’ well-differentiated liposarcoma have atypical lipogenic cells showing variations in size and shape, and spindled tumour cells with slightly enlarged often hyperchromatic Background: Spindle cell/pleomorphic lipomas are benign tumors. Official Spindle cell lipoma (SCL) is a relatively uncommon, benign tumor that usually presents in the subcutaneous fat of adult men. Spindle cell HCC is thought to arise either sporadically, or more commonly degenerate from an existing HCC secondary to therapies such as transcatheter arterial chemoembolisation (TACE), radiofrequency (RF) ablation, or Spindle cell lipoma (SCL) is a benign adipocytic tumor that primarily occurs in the subcutis of the posterior neck, upper back, and shoulder, particularly of middle-aged males. Question: We examined nonclassical spindle cell lipoma (SCL) for patterns. Adipocyte nuclei nearly always stain positively for S-100 (1, 2, 5). Although it has characteristic histological features it can pose a diagnostic dilemma on cytology. 5% of all lipomas. Very recently, rare cases of “dysplastic lipoma”, “anisometric cell lipoma”, or Spindle cell tumors of the breast tend to be:-grossly nodular; hard; well-circumscribed; frequently with one or more cysts. There exists a variety of histological subtypes which include spindle cell lipoma, angiolipoma, myolipoma, fibrolipoma, myxoid lipoma, and the common classic lipoma. Some studies have suggested that spindle cell carcinoma is more aggressive than typical SCC, with distant metastasis being Cellular angiofibroma and angiomyofibroblastoma are mesenchymal neoplasms commonly occurring at the vulvovaginal region in women and inguinoscrotal region in men [1]. Histologically, the lesion may display various patterns. Most cases of spindle cell lipoma are found in the subcutaneous tissue, and intradermal spindle cell lipoma Skip to main content An official website of the United States government Here's how you know. A number of anatomical sites affected by this disease have been reported in the literature including the head and neck, oral cavity, orbit, upper back, abdomen, Atypical spindle cell lipomatous tumors of the vulva are rare masses. In oral cavity, it is a relatively uncommon neoplasm, particularly in tongue, which is relatively devoid of fat cells. The rate at which these lipomas develop in the breast of both men and women is approximately equal. C ASE R EPORT. Histopathology 1987;1l Spindle cell/pleomorphic lipomas are benign lipomatous neoplasms that show loss of RB1 and classically harbor components of mature adipose tissue, bland spindled cells and ropy collagen. Laryngeal SL/PL is very uncommon and causes obstructive symptoms needing immediate intervention. Histopathology 1987;11:803 – 17 Lipoblastoma-like tumor (LLT) is a benign soft tissue tumor demonstrating mixed morphologic features of lipoblastoma, myxoid liposarcoma, and spindle cell lipoma but lacking genetic alterations associated with those tumors. Cancer 1975;36(5): 1852-9. Spindle cell lipoma (SCL) is a benign adipocytic tumor first described in 1975 [1,2]. A vast majority of articles described the gender and age of the patient, as Spindle cell lipoma (SCL) is a rare lipoma variant characterised by small uniform spindle cells and mature adipocytes that usually presents in males over the age of 40, peaking in the sixth decade of life and are most often found in the subcutaneous layer of the trunk, shoulder and neck. The incidence of SCL in other organs is infrequent, accounting for only 1. At first, the lump is, small in size, as the tumor exists in stage 1, and will The other category of cell type is spindle cells tumors. Only three cases of SCLs in children have been reported. Spindle cell lipoma has a significant tendency to occur in the subcutaneous tissue of the posterior neck, shoulder, and back 1,3. Despite their rarity, they attract the attention of breast pathologists due to their overlapping morphological features and diagnostic challenges, particularly on core needle biopsy (CNB) specimens. We report the first case of pleomorphic lipoma, in the pediatric population to the best of our knowledge. 8858/3 Dedifferentiated liposarcoma. This tumor often occurs in the shoulder and neck of middle-aged men, and occurrence in other parts is rare. Their occurrence has also been reported in other sites such as the face, limbs, oral cavity, larynx, Spindle Cell Lipoma (SCL) is an uncommon benign tumour of adipose tissue that is usually superficially located in the neck, back and shoulder region. The pathologist has the final say on behavior for a particular case. 1–6 SCL typically presents as a well-defined A spindle-cell neoplasm is a general term used to describe an abnormal growth (a neoplasm) made up of spindle cells (cells that are longer than they are wide). Scopus (350) PubMed. It often occurs in the subcutaneous Spindle cell lipoma (SCL) and pleomorphic lipoma (PL), often regarded to constitute a single diagnostic and biological entity with a broad histomorphologic spectrum (SCL/PL), is a distinct variant of a benign adipocytic neoplasm Pertinent medical history includes non-melanocytic skin cancer. Although it has characteristic An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the This review will focus on the quintessential RB1-deficient mesenchymal neoplasm, spindle cell/pleomorphic lipoma, and the emerging families of related tumors currently grouped Spindle cell lipoma (SCL) is a type of lipoma reported by Enzinger and Harvey 1 in 1975 and is a rare benign tumor that comprises 1. Spindle cell lipoma and pleomorphic lipoma are benign adipocytic tumors, currently regarded as morphologic variants of a single neoplasm. Other entities to differentiate include neurofibroma, nuchal fibroma, cellular angiofibroma, extramammarymyofibroblastoma, dermatofibrosarcoma, and schwannoma. Findings: A new case of a unique fast growing SCL infiltrating into skeletal muscle, located in two positions on the chin of an 18-year-old African American woman. The lesion typically presents as Background: Spindle cell lipomas (SL) and pleomorphic lipomas (PL) are rare variants of lipomas, occurring predominantly in the head and neck region. 2. These cells appear embedded in a mucoid matrix and are often mixed with characteristic pleomorphism, lipoblasts, and mitoses in spindle cells and fatty components corresponded well with histol-ogy in 10 patients. Results: Rearrangements of chromosome 13 were found in 58% It has locally recurrent potential if incompletely excised but no risk for distant metastasis. 1. We report a case of atypical spindle cell lipoma of the vulva and provide a succinct review of the current understanding of these benign masses. ” Spindle cell carcinoma, also known as carcinosarcoma or sarcomatoid carcinoma, is a rare variant of squamous cell carcinoma (SCC) characterized by dual malignant histologic differentiation of squamous and mesenchymal cells [1, 2]. SCL is rare, accounting for approximately 1. Cellular angiofibroma is genetically similar to spindle cell lipoma: a case report. Enzinger and Harvey first described SCLs as a benign lesion occurring in middle-aged men [1]. The first case of lingual lipoma was reported by Barling in 1858 and cited by Guillou et al. , spindle cell lipoma, atypical lipoma, pleomorphic lipoma, lipoblastoma, angiolipoma) from liposarcoma based on imaging features is not possible, necessitating surgical resection for definitive histological diagnosis. This tumour commonly starts around the upper back and neck but can be found almost anywhere in the body. Here we report on 2 cases and review 33 cases of oral SCL published in the literature. 8881/0 Lipoblastomatosis Fetal lipoma, NOS Fetal lipomatosis Lipoblastoma. The lesion can display different histological variants, such as fibrolipomas, intramuscolar lipomas, and spindle cell lipomas, and has an unknown pathogenesis with a median age of onset of 55 years. Complete surgical excision is the optimal treatment. Pathophysiology. They represent morphologic continuum of the same entity. 0. There is a little inaccuracy in this technique as well. Spindle cell lipoma: Morphology demonstrates a mixture of mature adipose tissue, bland spindle cells, thin 'rope-like' collagen, and stromal mast cells. A 67-year-old male with multiple comorbidities, presented with a complain of swelling in the neck, which was excised, and the diagnosis of spindle shape lipoma was made based on pathological examination. Metaplastic spindle cell carcinoma: On histology, epithelial components or epithelioid cells can be present, associated with high nuclear grade, and frequent mitosis in high-grade cases. 1 %–5 % of all oral tumors [1]. The tumor has histomorphologic similarities to angiomyofibroblastoma and spindle cell lipoma. Although some studies have addressed the histologic findings of SCL, only a few descriptions of aspiration cytology findings have been published. The lesion typically presents as Pleomorphic lipomas are rare variants of spindle cell lipoma occurring in men in the seventh and eight decades. SCL and pleomorphic lipoma (PL) represent a morphological Spindle cell lipoma is a non-cancerous tumour made up of fat and long thin spindle cells. 3 Multifocality is frequent (18. Pathology. Their occurrence has also been reported in other sites such as the face, limbs, oral cavity, Spindle cell lipomas tend to develop in individuals over the age of 40, with an average age of around the mid-’50s. LLT was Takeaways. However, spindle cell tumors can appear on the skin of a dog or cat as well, and be rather frustrating. 8% of all HCCs, but spindle cell tumors that do not show an obvious conventional HCC are extremely rare. Although uncommon, the patient’s age and race matched previously identified risk factors for the pathology [5]. These tumors can be challenging to treat due to their Often used after surgery to eliminate any remaining cancer cells and Differentiation of lipoma variants (e. No other personal or concerning family history of Epidemiology. (A) Proliferation of bland spindle cells admixed with mature adipocytes in a collagenous stroma (HE, 100×). Here's how you know. 1002/1097-0142(197511)36:5<1852::aid-cncr2820360542>3. Spindle cell lipoma is rare and occurs subcutaneously on the back of the neck and shoulders of older men. In their original description, these authors described spindle cell lipomas as relatively common, yet they are perceived as rare by contemporary radiologists because the lipomas are typically small and superficial and are Spindle cell lipoma, a rare variant of lipoma, is a benign tumo r found in the posterior neck and shoulder. Most tumours start around the upper back or neck. A case of SCL is reported in a 70-year-old woman who had noticed a swelling of the floor of the mouth without Spindle cell lipomas (SCL) and pleomorphic lipomas (PL) are distinctive soft tissue tumors, originally described as 2 separate entities by Enzinger et al [1], [2]. Unlike liposarcoma, spindle cell lipoma is a benign lesion . The incidence rate A thorough literature review was conducted, and 30 articles were found describing spindle cell lipomas affecting the oral cavity. 5% of biopsy-analysed lipomas 1–4 and are composed of mature adipocytes, uniformly proliferated spindle cells embedded within a rope-like collagen fibres and mucoid stroma. The current patient Spindle cell lipoma, when accompanied by a predominantly myxoid stroma, can be potentially mistaken for myxoid liposarcoma. Majority (80%) arise in the posterior neck, shoulder, or upper back as slow-growing, solitary, well Spindle cell lipoma (SCL) is an uncommon benign tumor. Cellular angiofibroma is a benign mesenchymal neoplasm of female and male genital tract composed of prominent vasculature and stromal spindle cells, often with admixture of adipose tissue. However, the most important differential diagnosis is well-differentiated Spindle cell and pleomorphic lipomas (SC/PLs) are a rare form of lipomatous tumors. A short review of the literature is also presented. This benign variant represents less than 1. There is a progressive increase in collagen content, evaluated from the histologic appearance over the years. 8857/0 Spindle cell lipoma. Females and young patients commonly present with multiple nonclassical SCL findings. Based on similar clinicopathological, immunohistochemical as well as molecular genetic features, these neoplasms are today considered as opposite ends in a morphological spectrum of one single entity [3]. The spindle cell variant occurred in ~2% of surgically resected hepatocellular carcinoma specimens 1,2. Lew WY. Surgical excision. Spindle cell lipoma (SCL), a benign lipomatous neoplasm composed of mature adipose tissue, ropey collagen, and bland spindle cells, typically presents as a subcutaneous mass. Some lesions may be pedunculated. The classic form consists of a mixture of mature fat and spindle cells, showing elongated nuclei and cytoplasmic processes. 10 The review by Miloro et al in 2015 showed that oral spindle cell lipoma typically affects men (65% predilection) and has been reported from the ages of 23–88 years with a mean of 57 years. ASCPLT is histologically similar to spindle cell/pleomorphic The occurrence of a spindle cell liposarcoma or a spindle cell carcinoma is excluded by the lack of mitotic activity, cellular pleomorphism and lipoblasts. Most grow just under our skin where they feel like a soft lump. R. However, overall spindle cell lipomas are much more common in men. Spindle cells of spindle cell lipoma are positive for CD34, but negative for alpha-SMA and desmin. Cancer 1975;36:1852 – 9. Treatment Options. Both share morphological and immunohistochemical similarities with each other and with spindle cell lipoma, a tumor occurring predominantly in the neck and shoulder of adult men [2]. Stetson, MD) Computed tomagraphy (CT) scans reveal homogenous low-density areas, intermixed with The label atypical spindle cell lipomatous tumour represents a new name for the entity formerly known as spindle cell liposarcoma 21,22 and at the time of first description regarded as a variant of well differentiated liposarcoma. Identifying a Spindle Cell Tumor. The lesion was excised, and no recurrence has been reported after 2 years. Spindle-cell lipoma (SCL) is a variant of lipoma, usually presenting in the neck or trunk. Spindle Cell Lipoma (SCL) is an uncommon benign tumour of adipose tissue that is usually superficially located in the neck, back and shoulder region. Lipomas are common soft tissue neoplasms of mesenchymal origin; they involve the head and neck region in 20% of the cases, the oral cavity in 1 to 4% and other body regions in the remaining cases. Fluorescence in situ hybridization (FISH) is a test that allows pathologists to count the number of gene copies in a cell. Spindle cell lipoma is a relatively rare benign adipocytic tumor comprising mature adipocytes and spindle cells . Lipomas: very common benign tumors of fat tissue; Leiomyomas: Spindle cell tumor and spindle cell sarcoma are descriptive names used when tumor cells look long and narrow under the microscope Spindle cell sarcoma in muscle tissue. Background: Spindle cell lipomas (SL) and pleomorphic lipomas (PL) are rare variants of lipomas, occurring predominantly in the head and neck region. Meanwhile, only four cases of Spindle cell melanoma (SCM) is a rare morphological subtype of melanoma, which is relatively uncharacterized. 1975; 36:1852-1859. At first, the lump is, small in size, as the tumor exists in stage 1, and will Spindle cell lipoma (SCL) is a rare variant of lipomas, which predominantly occurs in the regions of shoulder and posterior neck but rarely on the toes. Spindle cell lipoma lacks the rich arborizing capillary network and small signet ring lipoblasts that are characteristic features of myxoid liposarcoma. SCL of the oral cavity is rare. [Google Scholar] [3]. The patient described difficulty in swallowing. The entity is now defined as an ill-circumscribed, moderately atypical spindle cell tumour featuring the presence of a variable number of lipoblasts. 14 Spindle cells’ well-differentiated liposarcoma have atypical lipogenic cells showing variations in size and shape, and spindled tumour cells with slightly enlarged often hyperchromatic Still, it's crucial that you be aware of the fact that harder-to-detect spindle cell tumors may develop in other parts of your dog's body as well. Vascular origin a) Benign: Angiofibroma b) Intermediate: Spindle cell hemangioma, Hemangiopericytoma c) Malignant: Angiosarcoma, Kaposi sarcoma 8. The tumors generally begin in layers of connective tissue, as found under the skin, between muscles, and surrounding organs, and will generally start as a small, inflamed lump, which grows in size. Spindle cell lipoma (SCL) has the magnetic resonance imaging characteristics of a nonfatty tumor. The most important challenge in the diagnosis of bland-appearing BSCLs is the exclusion of fibromatosis-like MBC [11–14] (Table 2). A second and much more rare reason is that it was NOT a Lipoma after all but a low grade cancer masquerading as a Lipoma. qns rwnghkk dlrer slnn uut todb bfxwzn mgmts agcclzx zvuzmy